Affiliation:
1. Department of Microbiology, Annamalai University, Annamalai Nagar, Tamil Nadu, India
Abstract
ABSTRACT: Actinomycetes are one of the important secondary metabolite producers. Researchers focused on the exclusive marine areas for isolation and identification of marine actinomycetes. The present study focused on the isolation and identification of Nocardiopsis dassonovillei (ON627850) from TS Pettai region. The potential strainTSP1 showed effective antibacterial activity against Haemophilus influenza. TSP1 isolates showed IC50 value of 75.22 μg/ml effective antioxidant activity determined by DPPH assay. Cytotoxicity assay results were noted for the ethyl acetate extract of TSP1 screened against oral cancer cell lines (KB). The spectral characterization studies of UV, FT-IR and GC-MS results identified the compound 2,4-di-tert-butylphenol. The multi-potential 2,4-di-tert-butylphenol compound finally docked with KB cell lines protein for drug discoveries.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Agronomy and Crop Science,Biotechnology
Reference28 articles.
1. 1. Rosa, S. D., Mitova, M., Caro, S. D., & Tommonaro, G. New peptide from a bacterium associated with marine sponge Ircinia muscarum. In Biodiversity. 2002 ., 335-340.
2. 2. Pietra, F. Secondary metabolites from marine microorganisms: bacteria, protozoa, algae and fungi. Achievements and prospects. Natural product reports., 1997.,14: 453-464.
3. 3. Kamil, I., Talha, G., Fadime, Z. K., & Elif, C.Molecular identification of different actinomycetes isolated from East Black Sea region plateau soil by 16S rDNA gene sequencing. African Journal of Microbiology Research., 2014., 89: 878-887.
4. 4. Macagnan, D., Romeiro, R. D. S., de Souza, J. T., & Pomella, A. W. Isolation of actinomycetes and endospore-forming bacteria from the cacao pod surface and their antagonistic activity against the witches’ broom and black pod pathogens. Phytoparasitica, 2006., 34: 122-132.
5. 5. Lacey, J. Ecology of actinomycetes in fodders and related substrates. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1978