Affiliation:
1. Sultan-ul-Uloom College of Pharmacy, Banjara hills, Hyderabad-500034, Telangana, India.
Abstract
This article describe the preparation of valerianic acid loaded HPMC nanoparticles (NPs) using the nano-precipitation method. Objective of this study include enhancement of the dissolution rate of the poorly water soluble drug(Valerenic acid obtained from Valerianawallichii), and further more to look into the in vitro properties, zeta potential and surface characteristics of nanoparticles (percent yield of nanoparticles, percent encapsulation efficiency and in vitro release characteristics).In phosphate buffer medium at pH 6.8, the cumulative drug release from the original drug and nanoparticles were up to about 12% and 35%, respectively. Valerianic acid release can be enhanced by the use of nanoparticles loaded with hydroxy propyl methyl cellulose (HPMC), that also enhances bioavailability and patient compliance.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Agronomy and Crop Science,Biotechnology
Reference24 articles.
1. 1. Bhandarka, A.V.; Sashidhara and Deepak,M.(2014).Comparative anxiolytic activity of petroleum extracts of wallichii in mice. Journal of cology and toxic studies.,2(2):34-39.
2. 2. Bushra, P.;Abida, Parveen.;Rabea,P.; Sayeed, Ahmad and Muhammed, Iqbal.(2020). Challenges and opportunities for traditional herbal medicine today with special reference to its status in India.Ann. Phytomed., 9(2):97-112.
3. 3. Chan, H.K andKwok,P.C.L. (2011).Productionmethods for nondrug particles using the bottom up approach.Adv. Drug Deli. Rev., 63:406–416.
4. 4. Dali, S.V and Dave, R.N.(2009).Controlling particle size of a poorly water soluble drug using ultrasound and stabilizers in anti solvent precipitation. Ind. Eng. Chem. Res., 48:7581-7593.
5. 5. Dinesh, C.R.;Arvind andVinod, K.P.(2020).Optimization of coating material for encapsulation of flax seed oil containing omega-3 fatty acids.Ann. Phytomed.,9(2):277-282.