Potency of Balinese Kecombrang (Etlingeraelatior) Extract As Antioxidant Against The Activity of Superoxide Dismutase (SOD), Glutathione (GSH) And Fatty liver in Obese rats

Abstract

Kecombrang is a plant that contains many antioxidants such as polyphenols, tannins, saponins, flavonoids and steroids. The purpose of this study was to observe the potential of the ethanolic extract of kecombrang flowers and stems as an antioxidant on the activity of superoxide dismutase (SOD),glutathione (GSH)and fatty liver of obese wistar rats. This study used 24 rats divided into 4 treatment groups, namely the normal group (standard diet), group 1 (high fat diet), group 2 (high fat diet + 100 mg / kg bw kecombrang flowers extract) and group 3 (high fat diet + 100 mg / kg bw kecombrang stems extract). The treatment duration was 30 days and on the last treatment day, the rats were fasted for 14 hours and then their blood was taken and dissected for measurement of SOD, and GSH activity. Liver was taken for fatty liver analysis. The results showed that the extracts intake of kecombrang flowers and stems gave increase SOD and GSH concentrations and decrease fatty liver with significant differences (p <0.05).It can be concluded that the intake of kecombrang flower and stem extracts have the potential as an antioxidant against SOD, GSH activity, and reduce fatty liver.