Synergistic Activity of Green Tea and Seagrass Extract in the Regression of Alcohol Induced Liver Toxicity in Rats

Abstract

Liver, an important organ of the body, plays a key role in the anabolism of biomolecules along with detoxification of several xenobiotics. Thus, the protection of liver from alcohol toxicity and its causative effects such as steatosis, necrosis, fibrosis, cirrhosis and steato-hepatitis is of global concern.The consumption of alcohol results in the production of ROS and RNS in the liver thereby causing oxidative stress and free radical injuries. Therefore, reliable hepato-protective agents are at demand to combat against alcohol induced toxicity. At this point, we investigated the synergistic efficacy of aqueous extracts of Green tea and seagrassin the regression of liver damage induced by alcohol intoxication. Alcohol –induced rat models were adopted to perform biochemical and histo-pathological studies. The results demonstrated tremendous decline in alcohol induced hepatotoxicity with mixed extract which indicates the synergistic and supra additive activity of phytochemicals of both green tea and seagrass.