Cardiotoxic Drugs: An Insight into its Pathologic Mechanisms

Abstract

ABSTRACT: Cardiovascular diseases are among the major causes of mortality and morbidity worldwide Cardiotoxicity due to drugs is a common and significant adverse effect on cardiovascular health, acting through multifactorial pathological mechanisms. Drug-induced cardiotoxicity limits the use and further development of certain drugs. Keeping this in mind, this review discusses the crucial drug-receptor interactions involved in cardiotoxicity induced by some drugs such as cocaine, trastuzumab, isoproterenol, antidiabetic drugs like pioglitazone, theophylline, ergotamine, methysergide, anthracyclines, fluoropyrimidines, cisplatin, NSAIDs, and antiviral agents. The key receptors involved in the pathological mechanism behind the cardiotoxicity induced by these drugs are discussed, aiming to provide in-depth knowledge for future drug discovery and prevention of drug-induced cardiotoxicity.