Assessment of Analgesic and Anti-inflammatory Activity of Double-layered Diclofenac Diethylamine Transdermal Patch

Author:

Sharma Aditya1ORCID,Verma Navneet2ORCID

Affiliation:

1. 1School of Pharmaceutical Sciences, IFTM University, Moradabad-244102, Uttar Pradesh, India.

2. 2Pharmacy Academy, IFTM University, Moradabad-244102, Uttar Pradesh, India,

Abstract

Diclofenac Diethylamine has been used generally in the management of pain and inflammation caused by musculoskeletal disorders. The current study revealed the preliminary investigation into the analgesic and anti-inflammatory activities of an optimized double-layered transdermal patch of Diclofenac Diethylamine. The patch was prepared by using the hydrophobic acrylic polymer Eudragit RL 100 and the hydrophilic polymer Polyvinyl pyrrolidone K-30 in combination as the first layer of matrix type and pressure-sensitive acrylic adhesive Duro Tak 387-2510 as the second layer of drug-in-adhesive type patch. The solvent casting method was employed to prepare the transdermal patch over the backing membrane. We optimized the patch in terms of its concentration based on results exhibited by ex-vivo and in-vitro studies using FDC and the rat’s skin. This study was designed to assess the analgesic and anti-inflammatory effects of an optimized patch with the respective models in laboratory animals. In a comparison of the developed transdermal patch with commercially available Diclofenac Diethylamine gel (Volini gel), the developed patch was found to be statistically significant (p < 0.01) and effective for decreasing pain and inflammation symptoms. The findings of the study suggest that the prepared double-layered transdermal patch of Diclofenac Diethylamine can serve as the best carrier to provide a sustained effect for the management of pain and inflammation.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3