Antidiabetic and Hypolipidemic Potentials of Extract of Picris Babylonica in Streptozotocin-Induced Diabetic Model in Rats

Abstract

Objectives: To investigate the hypoglycemic and hypolipidemic potentials of Picris babylonica extract in streptozotocin (STZ) induced diabetes in rats. Methods: Animals were injected with 40mg/kg of STZ to induce diabetes, a common diabetic model. Development of the disease were assessed by measuring blood glucose level 3 days prior systemic administration of STZ and following STZ injection. Animals received 200mg/kg and 400mg/kg of Picris babylonica extract and 0.6mg/kg of glibenclamide, standard, by oral rout for 14 consecutive days. Results: Administration of the Picris babylonica extract significantly decreased serum blood glucose, total cholesterol, triglycerides, and low-density lipoprotein-cholesterol. In addition, high density lipoprotein-cholesterol level significantly enhanced as compared to standard. Conclusion: Picris babylonica extract demonstrated beneficial effects in lowering blood glucose and improving lipid profile, therefore, Picris babylonica extract could be developed as hypoglycemic and hypolipidemic therapy.