Oxidation of few Substituted Phenols and Reaction Mechanism by Heterocyclic Pyrazinium Chlorochromate and It's Biological Activity

Abstract

The current investigation focuses on the oxidation of phenol (Phenylic acid) and a few mono substituted phenols in a liquified ethanoic acid medium with pyrazinium chorochromate (PzCC) support. The reaction showed a first kinetic model in PzCC but a fractional order in phenols. The low dielectric constant of the process, which is helped by hydrogen ions, promotes the reaction. The reaction's speed is unaffected by an increase in ionic strength. Meta-substituted phenols, which rely on the field effect for oxidation, are more susceptible to the delocalized effect than para-substituted phenols. The positive proportionality constant (ρ) indicates the presence of an electron deficit reaction site in the slow stage. Non-linearity in the Hammett plot was seen for all of the substituted phenols. An efficient mechanism and rate law were proposed following the computation of the activation and thermodynamic variables. Several gram positive and gram negative, including Entrococcus, Proteus vulgaris, Mycobacterium tuberculosis, and fungi, including A. niger, Fusarium, and Trichoderma, were examined for the antibacterial activity of the compound PzCC using the agar well diffusion method.