Synthesis of CeO2-GO Nano Composite and its Impact on SOD1 Protein Through Computation Study: Molecular Docking
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Published:2023-10-30
Issue:5
Volume:39
Page:1287-1294
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Chitrarasu S.1ORCID, Selvam A.2ORCID, Yogapriya M.1ORCID, Boopath K. i3ORCID, Selvapriya K.4ORCID
Affiliation:
1. 1Department of Chemistry, Kalaignar Karunanidhi Government Arts College, Tiruvannamalai, (Tamilnadu), India. 2. 2Department of Chemistry, Panimalar Enginering College,Chennai,Tamilnadu,India. 3. 3Department of Chemistry, Pondicherry University, Kalapet, (Pondicherry), India. 4. 4Department of Bioinformatics, Pondicherry University, Kalapet, (Pondicherry), India.
Abstract
Motor neuron disease (MND) has become the most widespread neurodegenerative disease, like ALS, AD, and PD, affecting millions of human beings worldwide. Among these, ALS disease plays a major role in MND. The metal oxides have an essential role in neurodegenerative diseases. Cerium oxide nanoparticles have received a lot of attention in recent years as a potential future remedy for treating a variety of problems due to their redox activity, free radical scavenging capabilities, biofilm suppression, and other features. We are using molecular docking experiments to better understand the interaction of transition metal oxides (CeO2) with mutated and Non-mutated SOD1 proteins. Through the use of molecular docking studies, the structural relationship between amino acids, binding energy, and ligand efficiency was investigated. Auto-dock analysis also reveals that the CeO2 nanoparticle has significant binding energy. In this work, we synthesize a Cerium oxide/GO composite and examine its impact on mutant and non-mutant SOD1 proteins, as well as antioxidant assays (SOD3), anti-microbial activity, and CV analysis.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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