One-pot Multicomponent synthesis of 3-(substitutedphenyl)-5-oxo-3,4,5,6-tetrahydroimidazo[4,5-c] Pyrazole-2(1H)-carbaldehyde Derivatives Act as Antibacterial Agents

Abstract

A new class of 3-(substituted phenyl)-5-oxo-3,4,5,6-tetrahydroimidazo[4,5-c]pyrazole-2(1H)-carbaldehyde derivatives 5(a-l) was synthesized in four-component cyclocondensation one-pot reaction. This was done using the catalytic amount of Bleaching Earth Clay (pH 12.5 wt%) and PEG-400 as a sustainable solvent. The structures of the produced substances were verified using spectral and analytical data. In vitro antibacterial activity of the targeted compounds was examined against S. Typhi, E. coli, B. subtilis, and S. aureus. The outcome of antimicrobial screening explains that compounds 5a-l showed good to moderate activities.