One-pot Multicomponent synthesis of 3-(substitutedphenyl)-5-oxo-3,4,5,6-tetrahydroimidazo[4,5-c] Pyrazole-2(1H)-carbaldehyde Derivatives Act as Antibacterial Agents
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Published:2023-02-28
Issue:1
Volume:39
Page:167-171
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Muli Pravin Nandkumar1ORCID, Muley Megha Mukund2ORCID, Dawane Bhaskar Sadashiv1ORCID
Affiliation:
1. 1School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded-431606, (MS), India. 2. 2Nanded Pharmacy College, Nanded-431602, (MS), India.
Abstract
A new class of 3-(substituted phenyl)-5-oxo-3,4,5,6-tetrahydroimidazo[4,5-c]pyrazole-2(1H)-carbaldehyde derivatives 5(a-l) was synthesized in four-component cyclocondensation one-pot reaction. This was done using the catalytic amount of Bleaching Earth Clay (pH 12.5 wt%) and PEG-400 as a sustainable solvent. The structures of the produced substances were verified using spectral and analytical data. In vitro antibacterial activity of the targeted compounds was examined against S. Typhi, E. coli, B. subtilis, and S. aureus. The outcome of antimicrobial screening explains that compounds 5a-l showed good to moderate activities.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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