Synthesis and Spectroscopy Characterizations of Some New Bis 1,3-thiazolidin-4-ones Derived from 4-hydroxybenzaldehyde Substrate

Abstract

Over three major convenient steps, a series of some novel Bis-Schiff bases, and Bis 1,3-thiazolidin-4-one derivatives have been synthesized: Firstly, the etherification process through the reaction of the 4-hydroxybenzaldehyde substrate with o-, m-, and p-chlorobenzylchlorides under mild circumstances. Secondly, the condensation reaction between 4-((chlorobenzyl)oxy)benzaldehyde compounds with a number of aromatic diamines in an acidic environment produces the required Bis-Schiff intermediates. Finally, the practical cyclization step was finished by synthesizing the required Bis 1,3-thiazolidin-4-one products with 79-97% yields through refluxing reaction in benzene with thioglycolic acid.