Synthesis, Spectral, Antimicrobial and In vitro Antitumorous Studies of Copper based mulltidentate thiosemicarbazones

Abstract

This is a report of the studies conducted on the synthesis, spectral, biological viz. antibacterial and antitumorous activities of some Copper complexes synthesized from a multidentate thiosemicarbazone ligand, HL2. This is based on a reaction between a secondary amine viz.N-phenyl piperazine and an N-substituted heterocyclic ketone viz. 2-Benzoylpyridine. The ligand exhibits a multidentate mode of coordination through N,N,S donor atoms in the copper complexes. The electron paramagnetic Resonance studies of the complexes(solution spectra) at LNT in DMF shows typical axial spectra with distinct g-values, gǁ& g┴indicating a slightly distorted four coordinated planar geometry. The biological studies viz. antibacterial and antitumorous studies suggest their use as competent antibacterial and antitumor agents.