A Flexible Route to Synthesis and Molecular Docking of Some New Quinoline Derivatives through Imine and Cyclization Processes

Abstract

The current assignment depicts the structure of recent quinoline derivatives. This method begins with the structure of imine derivatives through the condensation reaction of ethyl 2-aminobenzoate with various substituted aliphatic aldehydes and ketones in the existence of sodium hydroxide as a catalyst. While the second step includes the intra-cyclization process of the imine compounds in presence of a base like tertiary butoxide that resolute installs the hydroxyl- group on the bicyclic skeleton and aromatic amines. The molecular docking program Flare V4.0 was applied to investigate the biological activities of divers produced compounds against E.coli bacteria. Spectral data support the compounds of each the recent outputs acquired during this assignment.