Affiliation:
1. Department of Kayachikitsa, Parul Institute of Ayurved, Parul University, AP Limda, Tal – Waghodia, Vadodara, Gujarat, India.
Abstract
Introduction: Kanakasava is the classical formulation known to have beneficial effects on bronchial asthma. This study deals with the objective to compare the phytochemicals present in Kanakasava, Kanakasava distillate, and Kanakasava nebulizer solution using gas chromatography-mass spectrometry (GC-MS) and to determine if Kanakasava nebulizer solution can be useful in managing respiratory diseases. Methods: Kanakasava, Kanakasava distillate and Kanakasava nebulizer solution were prepared accordingly and standard GC-MS analysis was performed on the samples. Results: The GC-MS analysis indicated the presence of 6, 13 and 10 important phytochemicals in Kanakasava, Kanakasava distillate and Kanakasava nebulizer solution respectively. Many chemicals acting on the respiratory system were found in all three forms of Kanakasava and some of the chemicals were having similar actions. Conclusion: Despite the fact that the phytochemicals found in the three of them differed due to molecular fragmentation during the whole process, the efficacy of the novel Kanakasava nebulizer solution remained unaffected.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
Reference48 articles.
1. Shukla SD, Swaroop Vanka K, Chavelier A, Shastri MD, Tambuwala MM, Bakshi HA, Pabreja K, Mahmood MQ, O’Toole RF. Chronic respiratory diseases: An introduction and need for novel drug delivery approaches. Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. 2020:1–31.
2. GOLD Guidelines for COPD 2020.
3. Krishna Ramanujan,2006. Common asthma inhalers cause up to 80 percent of asthma-related deaths, Cornell and Stanford researchers assert.
4. Chatkin JM, Dullius CR. The management of asthmatic smokers. Asthma Res Pract 2016;2(1):10. DOI: 10.1186/s40733-016-0025-7.
5. Bhaisajya Ratnavali, Kaviraj Govind Das Sen, Prof Siddhinand Mishra, Chaukhamba Surbharti Prakashan, Hikka-Swasa Rogadhikar Ch-16/15-119/ pg -468