Molecular Docking, Synthesis of Novel Schiff Base 1, 3-Thiazine Compounds from 3-Methoxy Chalcone and Evaluation of Their Anxiolytic Activity
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Published:2023-06-30
Issue:3
Volume:39
Page:746-754
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
S Sonu1ORCID, Gautam Girendra Kumar2ORCID, Mishra Arun Kumar3ORCID, Parveen Baby Rabiya3ORCID, Saini Rajat2ORCID, singh Harpreet1
Affiliation:
1. 1Faculty of Pharmacy, School of Pharmaceutical Sciences, IFTM University, Moradabad 244102, India. 2. 2Department of Pharmaceutical Chemistry, Shri Ram College of Pharmacy, Muzaffarnagar 251001, India. 3. 3Faculty of Pharmacy, Pharmacy Academy, IFTM University, Moradabad, 244102, India.
Abstract
As they represent a sizable class of naturally occurring and synthetic chemicals with potent biological activity in the pharmaceutical and biological fields, 1, 3 Thiazine heterocycles are of great interest. The goal of this project was to create the Schiff base. 3,-Methoxychalcone derivative of 1,3-thiazine. TLC, IR, 1HNMR, 13C NMR, each mass calculation were accustomed to identify the compositions of recently created targeted substances. Using an Elevated plus maze, the test compounds (B1–11) were examined for their ability to reduce anxiety. The most effective CNS medications were B1 and B8 compounds.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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