Antidiabetic Potential of Copper Oxide Nanoparticles Using Biological and Polymer Functionalized Method Mediated by Sarcostemma acidum Stem Extract

Abstract

The nano sized copper oxide material (CuONPs) were prepared by the greener way and an approach functionalized by polymer using Sarcostemma acidum stem extracts. The in-vitro anti-diabetic activity was studied through the α-glucosidase and α-amylase inhibitory methods were demonstrated in Sarcostemma acidum stem, biological synthesized CuONPs and polymerized CuONPs. The percentage inhibition at 100 μg/ml, 200 μg/ml, 300 μg/ml, 400 μg/ml and 500μg/ml concentrations of Sarcostemma acidum stem, biological synthesized and polymerised CuONPs showed dose dependent inhibition in α-amylase and α-glucosidase. Throughout the studies, polymerized CuONPs showed highest inhibition of α-amylase and α-glucosidase as compared with green synthesis.