Invitro Antidiarrheal and Antimicrobial Assessments of Phytofabricated Zinc Oxide Nanoparticles Through Curculigo Orchioides

Abstract

The green approach was discovered to be a cost-effective and environmentally sustainable technique for the production of metal oxide and metallic nanoparticles. In this study, Curculigo orchioides' aqueous leaf extract was used to create zinc oxide nanoparticles (ZnO Nps) utilizing a plant-mediated component. The important medicinal herb Curculigo orchioides plant extract and zinc acetate were used to effectively prepare the ZnO Nps. For the manufacture of ZnO Nps, 0.1 M zinc acetate and plant extract were combined in various ratios of 5:5, 6:4, 7:3, 8:2, and 9:1. The 5:5 ratio was fixed. The subsequent yellow adhesive was fully dried, gathered, and packaged for further investigation. The UV-Vis spectroscopic absorption band, which is unique to ZnO Nps, was seen at 357 nm. The X-ray diffraction (XRD) pattern was utilized to assess the average size of ZnO Nps. Results from Energy Dispersive Spectrum (EDX) analysis revealed the constitution of zinc and oxygen, with values of 41.59% and 30.89%, accordingly. FT-IR spectroscopy study revealed the Zn-O bonding absorption peak to be around 400 and 600 cm-1. Additionally, the antimicrobial and antidiarrheal assessments of the produced ZnO Nps were examined through the disc diffusion technique. This research led to the conclusion that numerous biomedical activities are employed by this plant.