Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation-Reference-Cited by-同舟云学术

Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation

Published:2023-08-30 Issue:4 Volume:39 Page:815-822
ISSN:2231-5039
Container-title:Oriental Journal Of Chemistry
language:en
Short-container-title:Orient. J. Chem

Author:

Hussein Weiam A.¹^ORCID,Bin Break Mohammed Khaled¹^ORCID,Alafnan Ahmed²^ORCID,Huwaimel Bader¹^ORCID,Khojali Weaam M. A.³^ORCID,Khalifa Nasrin⁴,Alshammari Farhan⁵,Albalawi Tahani S.⁶,Alshammary Ghaliah⁶,Alshammary Zhawah F.⁶,Almutairi Haya O.⁶,Alrasheedi Reem M.⁶,Fayad Shahad⁶

Affiliation:

1. 1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, 2240/Hail, Saudi Arabia.

2. 3Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha’il, 2240/Hail, Saudi Arabia.

3. 4Department of Pharmaceutical Chemistry, College of Pharmacy, Omdurman Islamic University, 14415/ Al Khartoum, Sudan

4. 5Department of Pharmaceutics, College of Pharmacy, University of Ha’il, 2240/Hail, Saudi Arabia.

5. 6Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, 11115, Khartoum, Sudan.

6. 7College of Pharmacy, University of Ha’il, 2240/Hail, Saudi Arabia.

Abstract

In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three antioxidants were changed to new derivatives to show that their biological effects as antioxidants would change. We also reviewed the anticancer effects of these medications (based on the SRB test) to find other biological effects that may be related to their chemical structural modifications. Moreover, SWISS ADME software was used to determine further ADME characteristics. Compound 2C had the highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C had good cytotoxicity (87.66 μM). Compound 2C also demonstrated excellent cytotoxicity against the other three cell lines with IC50 values of 5.049, 6.26, and 9.71 μM, respectively. After its antioxidant structure was tweaked, 1C might be a critical molecule for building a novel treatment for lung cancer.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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