Biomarkers of Systemic Lupus Erythematosus and Systemic Sclerosis diseases activity in a sample of Egyptian patients :Soluble Intercellular Adhesion Molecule-1 and Soluble Interleukin-2 Receptor, Case Control Study-Reference-Cited by-同舟云学术

Biomarkers of Systemic Lupus Erythematosus and Systemic Sclerosis diseases activity in a sample of Egyptian patients :Soluble Intercellular Adhesion Molecule-1 and Soluble Interleukin-2 Receptor, Case Control Study

Published:2019-09-13 Issue:3 Volume:12 Page:1207-1216
ISSN:2456-2610
Container-title:Biomedical & Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

A. Hegazy Gehan¹,Shaker Olfat²,Sayed Safaa³,Elzaher Amr Abd⁴,Fathy Khaled⁵,Wahby Iman⁶,Elsamanoudy Ayman⁷,Mustafa Hesham N.⁸

Affiliation:

1. Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 2Medical Biochemistry Department, National Research Centre, Cairo, Egypt.

2. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Egypt.

3. Rheumatology and Rehabilitation Department, Cairo University, Cairo, Egypt.

4. Internal Medicine Department, Ain Shams University, Cairo, Egypt

5. Internal Medicine Department, Ain Shams University, Cairo, Egypt.

6. Family and Community Medicine Department, Rabigh, King Abdul Aziz University, Saudi Arabia. 7Community and Occupational Health Department, Al Azhar University, Faculty of Medicine, Egypt.

7. Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

8. Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

Systemic Lupus Erythematosus (SLE) and systemic sclerosis (SSc) are systemic inflammatory autoimmune disorders characterized by a large spectrum of clinical and laboratory features. The aim of the present study was to investigate the possible use of serum level of soluble intercellular adhesion molecule-1(sICAM-1) and soluble interleukin-2 receptor (sIL-2Ra) as biomarkers for monitoring of SLE and SSc disease activity. Moreover, it aimed to compare the specificity and sensitivity as well as cut-off value of both biomarkers in a sample of Egyptian patients. 50 SLE patients, 30 SSc patients and 60 age and sex matched healthy controls were enrolled in our study. sICAM-1and sIL-2Ra were measured in serum samples obtained from all participants. In addition to Erythosedimentation rate (ESR), complete blood count (CBC), Antineuclearantibodies (ANA) estimation, disease activity of both diseases were also assessed. sICAM-1and sIL-2Ra levels were higher in SLE and SSc patients versus control. Both parameters are correlated with each other as well as the activity parameters. A cut-off levels of 455.59 (ng/ml) &2525935 (pg/ml) in both SLE & SSs respectively was observed with the highest specificity and sensitivity. It could be concluded that sICAM-1 and sIL-2Ra are noninvasive biomarkers for SLE and SSc that could play a pathophysiologic role in development and progression of both diseases. Moreover, sICAM-1 and sIL-2Ra are correlated with the disease activity at cut-off values of 455.59 (ng/ml) & 2525935(pg/ml) respectively.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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