Zinc Chloride Ameliorates the Adverse Effects of Silver Nitrates Compared to Silver Nanoparticle in Post-Natal Model of Toxicity.

Author:

Fehaid Alaa1ORCID,T. Elazab Sara2ORCID,G. Elhadidy Mona3ORCID,El Nashar Eman Mohamad4ORCID,Abdalla Asim Mohammed5ORCID,Al-Khater Khulood Mohammed6ORCID,Alghamdi Mansour Abdallah7,M. Elalfy Mahmoud1ORCID

Affiliation:

1. 1Forensic Medicine and Toxicology department, Faculty of Veterinary Medicine, Mansoura University, Egypt

2. 2Pharmacology department, Faculty of Veterinary Medicine, Mansoura University, Egypt

3. 3Medical physiology, faculty of Medicine, Mansoura University, Egypt, and Physiology department, faculty of Medicine, Albaha University, KSA

4. 4Department of Anatomy, college of Medicine, King Khalid University, Abha, Saudi Arabia. King Khalid University.

5. 5Department of Histology and Cell Biology college of Medicine, Benha University, Egypt.

6. 7Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Saudi Arabia.

7. 8Department of Anatomy, Genomics and Personalized Medicine Unit, college of Medicine, King Khalid University, Abha, Saudi Arabia.

Abstract

Silver nanoparticles have been shown to increase postnatal toxicity in breastfeeding female rats, with negative consequences for their offspring. We wanted to investigate more about the differences in toxicity between silver nitrates and silver nanoparticles, as well as the impact of zinc chloride treatment on the silver nitrates induced toxicity on female albino rats. For 21 days, breastfeeding female albino rats and their puppies were exposed to silver nitrates at dosages of 0, 50, and 100 mg/kg. The results demonstrated that silver nitrates were more hazardous than nano-silver, as evidenced by higher free radical release, increased MDA levels, and decreased antioxidant enzyme levels (SOD). In addition, the silver ions-treated group had higher levels of liver enzymes and creatinine. Zinc chloride treatment, in particular, had a protective impact and mitigated the negative effects of silver nitrates, as seen by the restoration of baseline levels of liver enzyme, creatinine, and antioxidant enzyme. In addition, zinc chloride therapies reduced the harmful effects of silver nitrates on liver and kidney tissues but not lung tissue.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

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