Fexofenadine HCl Microspheres – Can it be the First Line therapy for Allergic Disorders ?

Author:

Arefin Paroma1,Habib Md Shehan1,Mostafa Mohammad1,Chakraborty Dipankar1,Bhattacharjee reebash Chandra1,Arefin Md Saidul2,Karmakar Debabrata3

Affiliation:

1. 1BCSIR Chattogram Laboratories, Bangladesh Council of Scientific and Industrial Research, Bangladesh

2. 3Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh

3. 4Institute of Technology Transfer and Innovation, Bangladesh Council of Scientific and Industrial Research, Bangladesh

Abstract

Fexofenadine HCl is a second-generation antihistamine which is commonly used for allergic disorders. But it has low bioavailability. Intranasal corticosteroids (INCs) and Immunotherapy and Allergen Specific Immunotherapy (ASIT) are now commonly being suggested for the treatment of allergic disorders. Despite the fact that current treatment alternatives have been in use for decades, patient quality of life has remained static. The treatment options are not much explored for their respective adverse effects. Therefore, they are in desperate need of research. Fexofenadine HCl is available in the form of a suspension, tablet, or capsule. In our current study, we have explored whether microspheres can be the perfect dosage form of Fexofenadine HCl to treat allergic disorders considering the pharmacokinetics of the drug, available dosage forms options and the probable side effects of the current therapies.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Agronomy and Crop Science,Biotechnology

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