Affiliation:
1. Department of Biochemistry, Assistant Professor Dr Ambedkar College, Deekshabhoomi, Nagpur 440010, Maharashtra, India
Abstract
Obesity is a chronic metabolic disease that affects both the pediatric and adult populations. Adipose tissue acts as an endocrine organ which secretes various adipokines involved in fat mass regulation and energy balance via modulating the metabolic signalling pathways. Altered secretion of adipokines promotes multiple complications, including insulin resistance. The primary mechanism of action that underlines the involvement of adipokines in the development of insulin resistance includes phosphorylation/de-phosphorylation of insulin receptor substrate-1 (IRS-1) facilitate by other signalling molecules like a suppressor of cytokine signalling 1 (SOCS-1). Adipokines mediated insulin resistance further contribute to the development of atherosclerosis, dyslipidemia, fatty liver disease, cancer etc. Thus, this review provides recent updates on the role of resistin, lipocalin-2, RBP-4, chemerin, TNF-alpha and IL-6 adipokines in the progression of insulin resistance.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Agronomy and Crop Science,Biotechnology
Reference90 articles.
1. 1. Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018. NCHS Data Brief. 2020;(360):1-8.
2. 2. Luhar S, Timæus IM, Jones R, et al. Forecasting the prevalence of overweight and obesity in India to 2040. PLoS One. 2020;15(2):e0229438.
3. 3. Apovian CM. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. 2016;22(7):s176-s185.
4. 4. Li Y, Ding L, Hassan W, Abdelkader D, & Shang J. Adipokines and hepatic insulin resistance. Journal of diabetes research, 2013, 170532.
5. 5. Sacks G, Vanderlee L, Robinson E, et al. BIA-Obesity (Business Impact Assessment-Obesity and population-level nutrition): A tool and process to assess food company policies and commitments related to obesity prevention and population nutrition at the national level. Obes Rev. 2019;20 (2):78-89.
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