Association of cord blood des-acyl ghrelin with Apgar score and anthropometric measures in relation to its maternal one.-Reference-Cited by-同舟云学术

Association of cord blood des-acyl ghrelin with Apgar score and anthropometric measures in relation to its maternal one.

Published:2019-08-20 Issue:3 Volume:12 Page:1147-1154
ISSN:2456-2610
Container-title:Biomedical & Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

R. Abdelhamid Enas¹,Kamhawy Alyaa H.¹,H. Ahmed Hanaa²,Abu Shady Mones M.¹,Fathy Ahmed¹,F. Fahmy Reham¹

Affiliation:

1. Department of Childhealth, Medical Division, National Research Center (NRC), Cairo, Egypt, 33rd El Bohouth st, Former El Tahrir st, Dokki, Giza, POB:12311, Egypt.

2. Department of Hormones, Medical Division, National Research Center (NRC),Cairo, Egypt, 33rd El Bohouth st, former El Tahrir st, Dokki, Giza, POB:12311, Egypt.

Abstract

Ghrelin is a pleiotropic hormone that governs eating and energy equilibrium as well as promotes the release of growth hormone release. Although cord blood ghrelin has been correlated to the weight at birth and other anthropometric measures, the implication of des-acyl ghrelin in fetal and postnatal growth still not well understood. The goal of this research was to investigate the concentration of des-acyl ghrelin (DAG) in cord blood of appropriate for gestational age (AGA), small for gestational age (SGA) and large for gestational age (LGA) infants in order to elucidate their correlation with birth weight, anthropometric measures as well as apgar score of the newborn and relating them to maternal DAG levels. Cord blood specimens were procured from 25 SGA, 24 AGA infants and 25 LGA infants. Desacyl ghrelin, was quantified by ELIZA. A significant negative correlation has been found between cord ghrelin and neonatal anrthropometric measures( neonatal weight, height, head circumference, mean arm circumference) As well, a significant negative correlation has been detected between cord ghrelin and apgar score at 1 and 5 min. The current results shed the light on the critical role of DAG in the growth during the intrauterine period. Further studies are necessary to identify the exact mechanisms underlying the contribution of DAG in the growth of the fetus.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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