In-vitro Anti-urolithiasis Activity Evaluation of Acalypha rhomboidea Leaf Extract

Abstract

The present study explored the in-vitro evaluation of the anti-urolithiasis activity of Acalypha rhomboidea leaf extract. The powdered plant material was extracted using the maceration technique with water as solvent. After the extraction, the extract was subjected to preliminary qualitative analysis to identify the presence of phytochemicals. The phytoconstituents present in the extract are reducing sugars, phenolic compounds, flavonoids, alkaloids, tannins, saponins, terpenoids, glycosides, etc. Later aqueous extract was evaluated for anti-urolithiasis activity using the titrimetry method and percentage dissolution was calculated. In this method, neeri was used as a standard drug. The plant extract showed 82% percentage dissolution of calcium oxalate crystals indicating that the plant was more efficient in dissolving calcium oxalate when compared to standard drug.