Methyl Silicon (IV) Schiff Base Complexes: Synthesis, Coordination Behavior and Their Pharmacologically Significance as Antioxidant, Anti-Inflammatory and Anti-Diabetic Agents

Abstract

Schiff bases exhibit many pharmacological and biological properties. Here, methyl silicon (IV) complexes are formed by reacting methyl silicon alkoxides with alanine based ligand. Later, the pharmacological characteristics of these ligand and associated methyl silicon (IV) Schiff base complexes were assessed. The ligand and methyl silicon (IV) complexes underwent physical and spectral characterization, including IR, 1H-NMR, and 13C-NMR. Pharmacological activities show an increase in the number of organic groups as well as in the coordinating environment of silicon. All compounds exhibited antioxidant, anti-inflammatory, and anti-diabetic activities, but the methyl silicon (IV) Schiff base complexes demonstrated superior activities relative to the ligand.