Synthesis, Characterization and Cytotoxicity of Ni (II), Pd (II), Pt (II) Complexes with 6-Methoxy-2, 3, 4, 5-tetrahydropyridine (MTP)
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Published:2020-10-25
Issue:05
Volume:36
Page:903-907
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Ali Mohamad Hikmat1, Taha Al-Kattan Widad2, Mashal Al-Daly Zena2, Nafia Najim Ali2
Affiliation:
1. College of Education, University of Salahaddin, Erbil, Iraq. 2. College of Science, University of Mosul, Mosul, Iraq.
Abstract
Reaction of 2 moles of (MTP) with one mole of MCl2 gave colored complexes with general formula; [M(MTP)2Cl2]. [M = Ni+2, Pd+2, and Pt+2]. All synthesized complexes are well-characterized using, FT-IR, 1HNMR, 13C NMR, UV-Vis. Spectra furthermore of magnetic susceptibility, C,H,N analysis, and molar conductivity. The results illustrated that divalent metal ions were coordinated with the ligands through nitrogen atoms in square planar spatial arrangements. The complexes were screened for their cytotoxicity effects versus MCF-7 cell line and showed that [Pt(MTP)2Cl2] complex has good cytotoxicity in comparison with the other complexes.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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