Abstract
Human papilloma virus (HPV) related head and neck squamous cell cancer (HNSCC) has varying etiology, genetic as well as environmental factors involved and differential clinicicopathological features. HNSCC came in the limelight recently due to increased incidence rate and insucient diagnostic methods. This review will comprehensively focus on the characteristics of HPV associated HNSCC. It will provide an updated review of our understanding of HPV role in Oral squamous cell carcinoma (OSCC) known to date. Curruntly, three vaccines are available (Gardasil, Gardasil 9 and Cervarix). These vaccines prevent infections with HPV types 16 and 18 HPV-16 is most common type associated with HNSCC. HPV related HNSCC has better prognosis, does not mutate but inactivatestumor suppressor genes and therefore has comparatively better treatment options. However, there is still a need to improve our methods of sampling, HPV molecular assay and type of specimen to be used.
Publisher
CrossLinks International Publishers
Reference29 articles.
1. DeSanjoséS,SerranoB,CastellsaguéX, BrotonsM,MuñozJ,BruniL,etal.Human papillomavirus (HPV) and related cancers in theGlobalAllianceforVaccinesand Immunization(GAVI)countries.AWHO/ICO HPVInformationCentreReport.Vaccine 2012;30:D1-83
2. BansalA,SinghMP,RaiB.Human papillomavirus-associatedcancers:A growing global problem. International Journal ofAppliedandBasicMedicalResearch 2016;6:84
3. De Villiers EM, Weidauer H, Otto H, Zur Hausen H.PapillomavirusDNAinhumantongue carcinomas.Internationaljournalofcancer 1985;36:575-8.
4. Gillison ML. Human papillomavirus-associated headandneckcancerisadistinct epidemiologic, clinical, and molecular entity. Seminars in oncology: Elsevier; 2004. p. 744-54.
5. HumansIWGotEoCRt.Human papillomaviruses.IARCmonographsonthe evaluation of carcinogenic risks to humans/WorldHealthOrganization, International Agency for Research on Cancer 1995;64:1