Role of Curcumin as a Potential Immunomodulator to Adjunct Tuberculosis Treatment in Indonesia

Abstract

This study aimed to highlight and focus on curcumin’s role in enhancing the body defense mechanism against tuberculosis (TB) infection, using a narrative review. This review was identified by four search engines: PubMed, Science Direct, Research Gate, and Google Scholar. We found that as an immunomodulator, curcumin reduces the production of specific cytokines by inhibiting the transcription factor. In the same mechanism, curcumin also activates the host macrophages, dendritic maturation, and modulation of the antigen-presenting cell process. Curcumin also increases apoptosis as a defence mechanism against TB infection. Curcumin also increases B-cell proliferation and downregulates oxidative stress on B-cells. As results, curcumin is a potential immunomodulator that complements M. TB treatment, especially in Indonesia. It can be stated that curcumin is proven to be a promising strategy in complementing TB prevention also treatment.