Prevalence of Catheter-related Bloodstream Infection and Distribution of Multidrug Resistance Microorganisms among the Hospitalized Patients

Abstract

BACKGROUND: Central venous catheter (VC)-related bloodstream infection (CRBSI) is associated with high rates of morbidity and mortality in critically ill patients over the world. AIM: The aims study is to evaluate the prevalence of CRBSI and to identify some of the factors. METHODS: This was a retrospective, observational study carried out in the tertiary care hospital “Mother Theresa,” Tirana and American Hospital, Tirana, over a period of 3 years from January 2016 to December 2018. Data were collected retrospectively from various electronic sources shared by the hospitals and linked using patients’ unique medical record numbers. A total of 170 patients with indwelling VC were included in the study. The catheters were cultured using the standard procedure. Statistical analysis version SPSS-20 software was used for calculation of data. RESULTS: Overall 170 patients analyzed in this study, the prevalence of CRBSI results 58.8%. The positivity from the University Hospital Center (UHC) “Mother Theresa” resulted 65.1% (82/126 cases) and the positivity from American Hospitals (AH) resulted 40.91% (18/44 cases). Patients from UHC Mother Theresa were (odds ratio) 2.69 times higher in risk for CRBSI compared to patients from AH, for confidence interval 95% (1.33–5.44) p value resulted to be with strong association = 0.005. The average age resulted 59.68 ± 14.26, with minimum age 9 years old and maximum age 83 years old. The most infected age groups resulted patients with age 61–70 years old. Central VC had a higher positivity compared to other catheters types. Regarding the spectrum of bacteria implicated in CRBSI infections, Gram positive bacteria (67%) were the most predominant compared to Gram-negative bacteria (33%), but regarding the antimicrobial resistance, the Gram-negative bacteria resulted majority of multidrug resistance. CONCLUSION: The overall prevalence of CRBSI was 58.8%. Patients from Mother Theresa Hospital have the highest prevalence compared to patients of American Hospital. Men patients were the most predominant sex; age groups 61–70 years old presented the highest positive cases with CRBSI. Staphylococcus spp., Acinetobacter spp., Proteus spp., etc., were the most common isolate. We found antimicrobial resistance almost in all bacteria, but Gram-negative bacteria resulted majority of multidrug resistance.