Relationship between Anxiety and Fatigue in Leukemia Patients on Quality of Life with Nausea and Vomiting as an Intervening Factor

Abstract

AIM: This study aims to identify anxiety and fatigue in children with leukemia on the quality of life. METHODS: Current research was implemented through a descriptive study with a cross-sectional design on children suffering from leukemia and undergoing a series of chemotherapy cycles. Through this design, the researcher measured the dependent variable, independent variable, and mediator variable at the same time with a sample of 82 people. Data collection was further done using PEDSQL 3 for cancer module. Meanwhile, the analysis used is path analysis which involves nausea and vomiting as a mediator. RESULTS: The results showed that the factor that had a direct relationship with the child’s quality of life was nausea and vomiting (p < 0.05) which was then analyzed using Sobel analysis resulting that nausea and vomiting were not a mediator of fatigue and anxiety. Therefore, it is necessary to pay attention to every nursing care practitioner to intervene in order to reduce anxiety and fatigue in children according to their condition. CONCLUSION: Anxiety and fatigue together have a relationship with nausea and vomiting in pediatric patients suffering from leukemia and undergoing chemotherapy. Nausea and vomiting have a significant direct relationship with quality of life. Anxiety and fatigue have a direct relationship with quality of life without being mediated by nausea and vomiting variables.