The Symptom Characteristics and the Efficacy of Combining Therapies in Inpatients with Atopic Dermatitis: A Study on Vietnamese Population

Abstract

Background:  Currently, biologics and targeted disease-modifying therapies were developed to provide an effective control for adult with moderate-to-severe atopic dermatitis. This study aimed to describe clinical features, stages, and severity levels of the disease as well as to evaluate the therapeutic efficacy of the combining therapies in adults with atopic dermatitis. Methods: 128 patients with atopic dermatitis diagnosis based on the Rajka and Hanifi standards at the Inpatient Department of Can Tho Dermato-Venereology Hospital from May 2018 to May 2020 were recruited in this study. The clinical characteristics were recorded. The treatment response was evaluated through the improvement of clinical presentations and the altering SCORAD score.   Results: The study showed that people aged 60 and over made up the largest proportion of total investigated patients. Pruritus was the predominant symptom of atopic dermatitis. There was an association between xerosis symptom and disease severity. After two weeks of treatment, the mean of SCORAD score significantly decreased by more than halved. Additionally, 88.4% of patients showed an excellent response and there was no patient with non/poor improvement. Conclusions: Our study supports that the combination of therapeutic methods might reduce symptoms in atopic dermatitis patients, and thereby improving their quality of life.