Coronavirus Disease-19 and Liver Injury

Author:

Siregar Gontar Alamsyah,Siregar Ginanda Putra,Darmadi Darmadi,Ruslie Riska Habriel

Abstract

Coronavirus Disease (COVID)-19 is a pandemic since March 11, 2020. The total case is more than a half million worldwide. Liver injury is quite common in COVID-19 patients. Direct viral infection is possible due to the presence of angiotensin converting enzyme 2 in cholangiocytes and hepatocytes. Other proposed mechanisms are virus-induced cytopathic effects, inflammation process, hypoxia and shock, increased apoptotic activity, increased positive end expiratory effect, and drug-induced. The manifestation of liver injury is mild and transient with elevated liver enzymes, bilirubin, and gamma-glutamyl transferase levels. Deterioration of liver function can occur in subjects with COVID-19 and underlying liver injury. The management is principally supportive. Hepatoprotective drugs may be administered in severe cases.

Publisher

Scientific Foundation SPIROSKI

Subject

General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Baseline aspartate aminotransferase activity is closely related to COVID-19 mortality: A bidirectional cohort study;Journal of Research in Applied and Basic Medical Sciences;2023-07-01

2. The Association between Protein C and Antithrombin III Levels with the Severity of Coronavirus Disease-2019 Symptoms;Open Access Macedonian Journal of Medical Sciences;2022-04-21

3. Thrombosis and Coronavirus Disease-19: A Literature Review;Open Access Macedonian Journal of Medical Sciences;2022-01-17

4. Damage to the cardiovascular system in COVID-19;Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini;2021-03

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