Chitosan as Bone Scaffold for Craniofacial Bone Regeneration: A Systematic Review

Abstract

Background: The reconstruction of bone defect in the face and head is indispensable yet one of the most challenging procedure to date. Chitosan has emerged as a promising low-cost natural biopolymer for the bone scaffold as an alternative to surgery. This study aims to review the effectiveness of chitosan as a bone scaffold for craniofacial bone regeneration. Methods: This systematic review used Google Scholar and PubMed as database sources. Study selection using PRISMA diagram and Boolean operator to specify the study search. The quality assessment of the study used a checklist from Joanna Briggs Institute for experimental study. Result: We included 18 experimental studies, both in vivo and in vitro study—the in vivo study used animal subjects such as mice, goats and rabbits. The studies mostly used chitosan combined with other biomaterials such as demineralized bone matrix (DBM), genipin (GP), sodium alginate (SA), resveratrol (Res), polycaprolactone (PCL) and collagen, growth factor and stem cells such as bone morphogenic protein-2 (BMP-2), dental pulp stem cell (DPSC), and human umbilical cord mesenchymal stem cells (hUCMSC). Conclusion: Chitosan is a natural polymer with promising osteoconductive, osteoinductive and osteo-integrative effects in bone regeneration. Chitosan utilization for bone scaffolds combined with other biomaterials, growth factors, or stem cells gives better bone regeneration results than chitosan alone.