Abstract
BACKGROUND: Diabetes mellitus is a metabolic disease associated with unhealthy eating patterns, a lack of physical activity, obesity, smoking habits, and family history. Strobilanthes crispus (SC) contains antioxidant compounds known to exert a hypoglycemic effect during long-term interventions in non-diabetic samples.
AIM: This study sought to determine the effect of administering the extract of SC leaves on the blood glucose levels and blood serum lipid profiles of streptozotocin (STZ)-induced diabetic rats.
METHODS: A total of 30 male Rattus norvegicus rats were divided into control and treatment groups. The control groups consisted of negative (normal rats) and positive controls (diabetic rats), whereas the treatment groups consisted of diabetic rats administered with 3.2% and 16.8% SC leaf extract, and glibenclamide as the drug comparison groups. Blood samples were collected from the rats’ retro-orbital vein for the purposes of glucose level and lipid profile measurement before and after the induction of diabetes with STZ as well as 14 days after the intervention. The collected data were analyzed statistically by means of a one-way analysis of variance continued with Duncan’s multiple range test.
RESULTS: The results showed the rats to be hyperglycemic experienced changes in their lipid profiles following the induction of diabetes. The administration of 3.2% SC leaf extract for 14 days reduced the rats’ blood glucose levels, while the effect of the 16.8% SC leaf extract was more pronounced in terms of reducing the rats’ blood glucose levels and improving their lipid profiles (reducing the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, while increasing the high-density lipoprotein cholesterol levels).
CONCLUSIONS: This study found 16.8% SC leaf extract to exert a good hypoglycemic effect and leads to an improvement in the lipid profiles in diabetic rats.
Publisher
Scientific Foundation SPIROSKI
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