Factors Associated of Multidrug-Resistance Tuberculosis among Minangkabau Ethnicity in Indonesia

Abstract

BACKGROUND: Past tuberculosis therapy has been linked to an increased chance of developing multidrug-resistant tuberculosis (MDR-TB). Indonesia is placed 8th among the 27 nations with "high-burden" MDR-TB. AIM: The purpose of this study was to determine the risk factors associated of multidrug-resistance tuberculosis among minangkabau ethnicity in Indonesia. METHODS: The authors conducted a case control study. Data were gathered  in Dr. M Djamil General Hospital Padang, Lubuk Alung Hospital Pariaman and Primary Health Care in Padang Pariaman District from December 2019-March 2020. In this study, there were 73 cases (MDR-TB) and 219 controls (Tuberculosis) who were matched by age and sex. The sampling technique in this research was convenience sampling. Data were gathered from medical records. Bivariate and multivariate analysis were investigated using chi-square and logistic binary regression test. The data were analyzed using STATA version 14.2. Results: The risk factors for MDR-TB, cavitary pulmonary had the highest odds ratio (OR = 113.54 [95% CI 15.02-858.54]), followed by TB outside the lung (OR = 38,68 [95% CI 4.89-305.43]), nutritional status (OR = 10.92 [95% CI 5.79-20.56]), alcohol consumption (OR = 6.45 [95% CI 1.57-26.48]), working status (OR = 4.08 [95% CI 2.33-7.17]), level of education (OR = 2.79 [95% CI 1.61-4.85]), history of close contact to patients with MDR-TB and TB (OR = 2.35 [95% CI 1.30-4.22]) and diabetes mellitus (OR = 2.12 [95% CI 1.15-3.91]). Multivariate analysis found that patients with a cavitary pulmonary was significant dominant factors for MDR-TB. Conclusion: MDR-TB was predicted by previous tuberculosis therapy and cavitary pulmonary disease.