Author:
Dinh Huu Nghi,Nguyen Huu Sau,Le Thi Xuan,Nguyen Van Thuong,Thi Minh Phuong Pham,Trinh Minh Trang,Hoang Van Tam,Cam Van Tran,Le Huyen My,Tran Hau Khang,Gandolfi Marco,Satolli Francesca,Feliciani Claudio,Tirant Michael,Vojvodic Aleksandra,Lotti Torello
Abstract
BACKGROUND: Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids.
AIM: To evaluate the efficacy of bleomycin injected in the injury for keloids treatment.
METHODS: The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times.
RESULTS: Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%).
CONCLUSION: The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.
Publisher
Scientific Foundation SPIROSKI
Cited by
13 articles.
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