Absolute Neutrophil Count Levels among Degree of Differentiation and Tumor Location in Colorectal Cancer Patients in Medan

Abstract

BACKGROUND: Absolute Neutrophil Count (ANC) recently a derived score composed of white blood cell and has been evaluated in a large number of the malignancy. AIM: The aim of this study was to investigate ANC levels among degree of differentiation and tumor location in Colorectal Cancer (CRC) in Medan. METHODS: This study was a cross-sectional analytical study on eighty consecutive patients with CRC. Data collection was obtained from the medical record of the patient at Adam Malik General Hospital, Medan, Indonesia. Inclusion criteria were included male or female aged ≥ 18 years old, the patient with CRC, blood test especially ANC, and the patient with histopathology test. The exclusion criteria were defined as a patient with chemotherapy, HIV, and the patient with sepsis. Data were analyzed with SPSS for window version 21. RESULTS: here were Rectal cancer 49.4%, Left side colon cancer 43.2%, and Right-side colon cancer 6.2%. Histopathological findings well differentiated 40.7%, moderate differentiated 32.1%, and poorly differentiated 25.9%. This study showed that no significant differences between ANC and location of the tumor (p = 0.951), but ANC level was significant in histopathological findings (p = 0.0001). CONCLUSION: ANC increased in poorly differentiated, and location of the tumor is left side colon cancer.