Occult Hepatitis (B) Infection in Hepatitis (C) Virus Infection Patients after the Treatment with Direct Acting Antiviral Drugs

Abstract

Background: The prevalence of occult hepatitis B ranges widely in patients with hepatitis C. This may have an impact on treatment of hepatitis C. Aims: The current study aimed to evaluate the prevalence of occult hepatitis B infection in chronic hepatitis C patients who finished the course of treatment with direct acting antiviral drugs and it’s correlation with treatment failure. Setting: Outpatient Clinic of Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt. Patients and methods: This study was conducted on 900 Egyptian patients chronically infected with HCV. All patients tested positive for serum real time polymerase chain reaction for HCV- RNA and received DAAs therapy for 12 weeks. Patients were categorized to:  Group I: 450 patients with chronic hepatitis C after direct antiviral treatment who responded to treatment. Group II: 450 patients with chronic hepatitis C after direct antiviral treatment who didn’t respond to treatment. All patients were submitted to clinical examination, laboratory investigations and abdominal ultrasonography. Detection of HBV- DNA and HCV- RNA was performed by PCR. Results: The prevalence of OBI detected in sera of HCV patients was 10.6 % (96/900). The present study showed no significant correlation between prevalence of OBI and virologic failure (p-value: 0.084).  There was no statistically significant difference (p-value > 0.05) between the studied groups as regard prevalence of OBI. Conclusion: The prevalence of OBI was 10.6% in patients chronically infected with HCV. OBI doesn't affect the anti-HCV DAAs outcomes.