The Correlation between High Sensitive C-reactive Protein Levels and Gensini Score in Diabetes Patients

Abstract

BACKGROUND: Coronary artery disease is a disease caused by atherosclerotic plaques in the coronary arteries. The severity of coronary artery disease can be assessed objectively by coronary angiography. Many prospective studies have shown that inflammatory biomarkers with high sensitivity C-reactive protein (hsCRP) are independent predictors of cardiovascular events. AIM: The aim of this study was to determine the correlation of hsCRP and Gensini score in subjects with coronary artery disease and diabetic patients. METHODS: This study used an analytical observational design with a cross-sectional study to see the correlation between hsCRP and Gensini score in coronary artery disease subjects. The total sample was 40 subjects with a diagnosis of coronary artery disease and diabetes. Examination of angiography and hsCRP levels was performed on all subjects. RESULTS: A total of 40 diabetic patients were included in the analysis. The mean age in this study was 57.98 ± 8.71 years old. The mean Gensini score in this study was 63.90 ± 40.79 years old. The median hsCRP level in this study was 13.05 (0.3–245.6). There was a significant correlation between hsCRP levels and the Gensini score (r = 0.346, p = 0.029). CONCLUSION: There was a significant positive relationship between hsCRP levels and Gensini score, where an increase in the hsCRP value was also followed by an increase in the Gensini score; therefore, the hsCRP value can be used to assess the degree of coronary artery disease lesions.