Affiliation:
1. Federal State Institution «V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology» of the Russian Federation Ministry of Health
Abstract
Currently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation of the disease. In the framework of the biopsychosocial concept, a hypothesis has been formulated about the importance of the polymorphism of the COMT and ADRB-2 genes for the development of SDJ TMJs, which make these individuals “vulnerable” to the development of chronic pain syndromes. It was found that a decrease in COMT activity leads to an increase in the level of catecholamimes, in particular, such as adrenaline, which contribute to the formation of persistent pain states by stimulating β2-adrenergic receptors in the peripheral and central nervous system.
Publisher
V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology
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