Pharmacogenetics of chemical addictions

Author:

Krupitsky E. M.1,Akhmetova E. A.2,Asadullin A. R.2

Affiliation:

1. V.M. Bekhterev national research medical center for psychiatry and neurology

2. V.M. Bekhterev national research medical center for psychiatry and neurology; Bashkir State Medical University

Abstract

An overview of a number of research papers examines application of pharmacogenetic tests in narcology. It has been proven that a system of pharmacogenetic tests can be used for the development of a polygenic predictive system which can provide a preliminary forecast of effectiveness and tolerability of a treatment as part of the individualization of addiction pharmacotherapy. Moreover, methods of genetic engineering can be a new emerging approach in the treatment of addiction.

Publisher

V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology

Reference48 articles.

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2. Krupitsky E.M. The use of pharmacological agents to stabilize remissions and prevent relapse in alcoholism: foreign studies. Voprosy narkologii. 2003;1:51-61. (In Russ.)

3. Krupitsky E.M. Short-term intensive psychotherapeutic intervention in narcology from the standpoint of evidence-based medicine. Nevrologicheskiy vestnik. 2010;42(3):25-27. (In Russ.)

4. Krupitsky E.M., Kibitov A.O., Blokhina E.A., Verbitskaya E.V., Brodyansky V.M., Alekseeva N.P., Bushara N.M., Yaroslavtseva T.S., Palatkin V.Ya., Masalov D.V., Burakov AM, Romanova T.N., Sulimov G.Yu., Kosten T., Nielsen D., Zvartau E.E., Woody D. Stabilization of remissions in patients with opium addiction Naltrexone implant: pharmacogenetic aspect. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2015:115(4):14-23. (In Russ.).

5. Krupitsky E.M., Rybakova K.V., Skurat E.P., Mikhailov A.D., Neznanov N.G. Double-blind, randomized, placebo-controlled study of the effectiveness of the use of pregabalin for the treatment of alcohol dependence syndrome. Voprosy narkologii. 2017;8:81-82. (In Russ.)

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