Pleiotropic effects of Metadoxil in the treatment of acute and chronic alcohol intoxications-Reference-Cited by-同舟云学术

Pleiotropic effects of Metadoxil in the treatment of acute and chronic alcohol intoxications

Published:2023-10-20 Issue:3 Volume:57 Page:98-106
ISSN:2713-055X
Container-title:V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY
language:
Short-container-title:V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

Author:

Bykov Yu. V.¹^ORCID,Bekker R. A.²^ORCID

Affiliation:

1. Stavropol State Medical University

2. An independent researcher in psychopharmacology

Abstract

This article presents a review of modern scientific data concerning the safety and efficacy of the use of Metadoxil at different stages of the treatment of alcohol use disorder (from acute alcohol intoxication to the alcohol withdrawal syndrome, to the post-withdrawal period and remission stabilization), as well as a review of the advantages of Metadoxil use in such patients, due to the neuro- and hepatoprotective effects of this medication. Authors also describe a clinical case from their own practice. In the aforementioned case, the use of Metadoxil as a part of combination therapy contributed not only to the stabilization of remission of the alcohol use disorder, but also to diminishing of symptoms of comorbid mental (obsessive-compulsive disorder) and somatic (alcoholic fatty liver disease) diseases.

Publisher

V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology

Reference38 articles.

1. Barancevich ER, Kurashevich KG. Prospects for identifying and treating alcoholic encephalopathy at an early stage of the disease. Uchenye zapiski SPb-GMU im. I.P. Pavlova. 2015;22(4):83-86. (In Russ.).

2. Bezvulyak EI, Basharin VA, Epifantsev AV, Kutsenko VP, Seliverstov PV. Prevention options of toxic drug-induced liver disease in patients with chemotherapy of oncological diseases. Meditsinskij sovet. 2020;5:40-47. (In Russ.).

3. Vinnikova MA, Ivanec NN, Nenast’eva AYu, ZHirov IV. Metadoksil in therapy of alcohol withdrawal syndrome, alcoholic liver disease and alcoholic polyneuropathy. Narkologiya.2014;13(10):48-54. (In Russ.).

4. Vishneveckaya T.P., Sergeeva T.A., Plotnickij V.A. Sravnitel’noe izuchenie antidotnoj terapii pri otravlenii paracetamolom. Mnogoprofil’naya klinika v reshenii problem onkologicheskogo pacienta: Nauchno-prakticheskaya konferenciya, posvyashchennaya 55-letiyu SPb bol’nicy RAN - Sankt-Peterburga. 2017. (In Russ.).

5. Voznyuk O.P. Osobennosti diagnostiki i kliniki tserebral’nyh ishemicheskih insultov u lits trudosposobnogo vozrasta na fone ostroi alkogol’noi intoksikatsii : dissertation. Rossijskij nautschno-issledovatel’skij neirokhirurgicheskij institut im. A.L. Polenova, 2012. (In Russ.).