Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms

Author:

Grinevich V. P.1ORCID,Nemets V. V.2ORCID,Krupitsky E. M.3ORCID,Gainetdinov R. R.4ORCID,Budygin E. A.1ORCID

Affiliation:

1. Sirius University of Science and Technology, FD Sirius

2. St. Petersburg State University

3. V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; St.-Petersburg First Pavlov State Medical University

4. Sirius University of Science and Technology, FD Sirius; St. Petersburg State University

Abstract

Using animal models that translate key features of alcohol dependence, the field has faced remarkable achievements in identifying neurochemical substrates of this disease with dopamine and norepinephrine playing significant role. Moreover, recent utilization of optogenetics in alcohol research provides with an opportunity in specifying patterns of neurotransmission within dopaminergic and noradrenergic neural circuits that govern ethanol-addictive behavior. This review summarizes experimental findings to demonstrate the effectiveness of the latest technologies in revealing the mechanisms bridging catecholamines’ specific changes with alcohol seeking, consummatory and relapsing behaviors.

Publisher

V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology

Reference162 articles.

1. Panchenko LF, Brusov OS, Balashov AM, Grinevich VP, Ostrovsky YM Interactions of some tetrahydroisoquinoline alkaloids with opiate receptors in the rat hypothalamus and midbrain. Vopr Med Khim. 1982;28(5):88-92. (In Russ).

2. Patsenko AA, Grinevich VP. High potency of tetrahydroisoquinolines to dopamine high affinity binding sites in rat striatum. Neurokhimiya. 1988;79(1):33-38. (In Russ).

3. Patsenko AA, Grinevich VP, Olshevskaya AB Radiochemical micromethod for the determination of the catehol-O-methyltransferase activity in rat tissues. VINITI.1987;2830-B87:1-9. (In Russ).

4. Patsenko AA, Grinevich VP, Ostrovsky YuM. Interaction of simple tetrahydroisoquinolines with opiate and high-affinity dopamine (D3) receptors in the rat corpus striatum. Farmakol. Toksikol. 1987; 50:33-35. (In Russ).

5. Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Touriño C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci. 2011;31(30):10829-10835. https://doi.org/10.1523/jneurosci.2246-11.2011

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3