Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion-Reference-Cited by-同舟云学术

Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion

Published:2016-11-01 Issue:6 Volume:6 Page:277-284
ISSN:2168-9709
Container-title:Mental Health Clinician
language:en
Short-container-title:

Author:

Boggs Douglas Lee¹,Peckham Alyssa²,Boggs Angela A.³,Ranganathan Mohini⁴

Affiliation:

1. (Corresponding author) Clinical Pharmacy Specialist-Outpatient Psychiatry, VA Connecticut Healthcare System, West Haven, Connecticut; Associate Research Scientist, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, Douglas.Boggs@yale.edu;

2. PGY-2 Psychiatry Pharmacy Resident, VA Connecticut Healthcare System, West Haven, Connecticut;

3. Clinical Pharmacy Specialist-Outpatient Psychiatry, VA Connecticut Healthcare System, Newington, Connecticut;

4. Attending Psychiatrist, VA Connecticut Healthcare System, West Haven, Connecticut; Abraham Ribicoff Research Facilities, and Assisstant Professor, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut

Abstract

Abstract Cannabis is being increasingly used as a medical treatment for a variety of illnesses. However, the cannabis plant has more than 70 different phytocannabinoids with potential pharmacologic activity. Two of the most researched phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Evidence suggests CBD can decrease some of the psychomimetic effects of THC. This has led to the development of a new drug, Nabiximols, for the treatment of moderate to severe spasticity due to multiple sclerosis. A discussion of evidence supporting proposed pharmacodynamic interplay between CBD and THC is presented.

Publisher

College of Psychiatric and Neurologic Pharmacists (CPNP)

Subject

General Medicine

Link

http://meridian.allenpress.com/mhc/article-pdf/6/6/277/2096522/mhc_2016_11_277.pdf

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