N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain-Reference-Cited by-同舟云学术

N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain

Published:2023-02-28 Issue: Volume: Page:85-106
ISSN:2692-3106
Container-title:Exploration of Medicine
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Author:

Choudhary Shikha¹,Kaur Raminderjit¹,Waziri Aafrin²^ORCID,Garg Arun³^ORCID,Kadian Renu⁴^ORCID,Alam Md Sabir⁵^ORCID

Affiliation:

1. School of Medical and Allied Sciences, K.R. Mangalam University, Gurugram 122103, Haryana, India

2. University School of Biotechnology, Guru Gobind Singh Indraprastha University, Delhi, 110078, India

3. Department of Pharmacology, NIMS Institute of Pharmacy, NIMS University, Jaipur 303121, Rajasthan, India

4. Ram Gopal College of Pharmacy, Gurugram 122506, Haryana, India

5. SGT College of Pharmacy, SGT University, Gurugram 122505, Haryana, India

Abstract

Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (PrialtTM) had been developed as the new drug, which belongs to the class of ω-conotoxin MVIIA. It inhibits N-type calcium channels. Ziconotide is under the last phase of the clinical trial, a new non-narcotic drug for the management of NP. Synthetically it has shown the similarities with ω-conotoxin MVIIA, a constituent of poison found in fish hunting snails (Conus magus). Ziconotide acts by selectively blocking neural N-type voltage-sensitized Ca2+ channels (NVSCCs). Certain herbal drugs also have been studied but no clinical result is there and the study is only limited to preclinical data. This review emphasizes the N-type calcium channel inhibitors, and their mechanisms for blocking calcium channels with their remedial prospects for treating chronic NP.

Publisher

Open Exploration Publishing

Subject

General Medicine

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