Relationship between gingival and peri-implant sulcular fluid active matrix metalloproteinase-8 concentration and clinical indices in healthy and diseased conditions-Reference-Cited by-同舟云学术

Relationship between gingival and peri-implant sulcular fluid active matrix metalloproteinase-8 concentration and clinical indices in healthy and diseased conditions

Published:2024-04-22 Issue: Volume: Page:243-256
ISSN:2692-3106
Container-title:Exploration of Medicine
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Author:

Guarnieri Renzo¹^ORCID,Reda Rodolfo²^ORCID,Zanza Alessio³^ORCID,Xhajanka Edit⁴^ORCID,Patil Shankargouda⁵^ORCID,Di Nardo Dario⁶^ORCID,Testarelli Luca³^ORCID

Affiliation:

1. Private Periodontal Implant Practice, 31100 Treviso, Italy; Department of Prosthodontics and Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India

2. Department of Prosthodontics and Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India; Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy

3. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy

4. Department of Prosthetic Dentistry, Faculty of Dentistry, Medical University of Tirana, 1001 Tirana, Albania

5. Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India; College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA

6. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy; Operative Research Unit of Dentistry, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy

Abstract

Aim: The study was to evaluate the active matrix metalloproteinase-8 (aMMP-8) concentration in gingival crevicular fluid (GCF) and in peri-implant sulcular fluid (PISF) in healthy and diseased conditions, before and after non-surgical treatment, and to compare it with the various clinical parameters used to estimate the gingival and peri-implant inflammation. Methods: Plaque index/modified PI (PI/mPI), gingival index/simplified GI (GI/sGI), probing depth (PD), bleeding on probing index/modified BOPI (BOPI/mBOPI), radiographic bone loss/radiographic marginal bone loss (rBL/rMBL), and GCF/PISF samples were evaluated, before and 3 months after non-surgical treatment, GCF/PISF samples were analyzed by a chair-side mouth-rinse test (ImplantSafe®) in combination with a digital reader (ORALyzer®). Results: In all groups, aMMP-8 median levels were statistically higher in the PISF than in GCF and they did not change after treatment. Moreover, it was statistically higher in Group 3 (periodontitis/peri-implantitis) compared to the other groups. A positive correlation of the GCF/PISF and aMMP-8 median concentration was seen with increasing PD and BOPI/mBOPI values. A higher covariation of aMMP-8 mean levels in GCF with PD was found when compared to PISF levels. aMMP-8 mean levels in PISF expressed a higher covariation with increasing grades of sGI, rMBL, and BOPI while aMMP-8 GCF concentration established a better covariation with PD and PI. Conclusions: PISF of sites with peri-implant mucositis and peri-implantitis showed higher levels of aMMP-8 compared to sites with gingivitis and periodontitis. Compared to clinical indices, aMMP-8 concentration in GCF/PISF can be a beneficial adjunctive diagnostic tool for early identification and screening of the risk of peri-implant diseases. After non-surgical therapy, PISF aMMP-8 concentration remained mostly unchanged, while the GCF concentration of aMMP-8 significantly decreased.

Publisher

Open Exploration Publishing

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