Effect of overweight and obesity on spirometric parameters in children and adolescent with asthma-Reference-Cited by-同舟云学术

Effect of overweight and obesity on spirometric parameters in children and adolescent with asthma

Published:2023-05-30 Issue: Volume: Page:323-332
ISSN:2692-3106
Container-title:Exploration of Medicine
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Author:

Khramova Regina N.¹^ORCID,Eliseeva Tatyana I.¹^ORCID,Tush Elena V.¹^ORCID,Ovsyannikov D.Yu.²^ORCID,Bulgakova Vilya A.³^ORCID,Ignatov Georgii S.⁴^ORCID,Oganyan Lamara A.¹^ORCID,Khaletskaya Olga V.¹^ORCID

Affiliation:

1. Pediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian Federation

2. Medical Institute, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation

3. Pediatrics and Child Health Research Institute, Petrovsky National Research Centre of Surgery, 119992 Moscow, Russian Federation; Pirogov Russian National Research Medical University, 117513 Moscow, Russian Federation

4. Faculty of Informatics, Mathematics and Computer Science, Direction of Business Informatics, National Research University Higher School of Economics, 603014 Nizhny Novgorod, Russian Federation

Abstract

Aim: Being overweight and obesity are factors in the negative modification of bronchial asthma (BA). The mechanisms of the aggravating effect of obesity on the course of BA have not yet been fully determined, but include changes in external respiration. The aim of the study was to study the effect of being overweight/obesity on spirometric parameters and on the occurrence of dysanapsis in children and adolescents with BA. Methods: It was a cross-sectional, open, single-center study. The data were obtained from 428 patients with atopic BA aged 7 years to 17 years, 12.0 [9.0; 14.0], and 72.9% (312/428) of them were boys. The children were divided into 3 groups: group 1—normal body weight; group 2—overweight; and group 3—obesity. All participants underwent spirometry, the ratio of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) was calculated and the diagnosis of dysanapsis was performed. Results: As body weight increases, a progressive decrease in FEV1/FVC is revealed—group 1: 79.55% [71.37; 85.43]; group 2: 76.82% [70.12; 82.03]; and group 3: 76.28% [67.04; 79.89] P = 0.004; as well as a decrease in Z FEV1/FVC: group 1—1.23 [–2.18; –0.28]; group 2—1.54 [–2.19; –0.68]; and group 3—1.75 [–2.63; –0.90] P = 0.02. Dysanapsis was detected in 37.7% (159/428) of patients. The incidence of dysanapsis increased statistically significantly with increasing body mass index (BMI) and amounted to: with normal body weight—31.7% (77/243), with overweight—42.0% (55/131), and with obesity—50% (27/54) P = 0.016. Conclusions: In children and adolescents with BA, as BMI increases, there is a statistically significant decrease in the ratio of FEV1/FVC, and, consequently, bronchial patency; the incidence of dysanapsis also increases statistically significantly. Taken together, this indicates the formation of an obstructive pattern of external respiration under the influence of being overweight and obesity in children and adolescents with BA.

Publisher

Open Exploration Publishing

Subject

General Medicine

Reference29 articles.

1. Bray GA, Kim KK, Wilding JPH; World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes Rev. 2017;18:715–23.

2. Marillier M, Bernard AC, Reimao G, Castelli G, Alqurashi H, O’Donnell DE, et al. Breathing at extremes: the restrictive consequences of super- and super-super obesity in men and women. Chest. 2020;158:1576–85.

3. Jung Y, Jean T, Morphew T, Galant SP. Peripheral airway impairment and dysanapsis define risk of uncontrolled asthma in obese asthmatic children. J Allergy Clin Immunol Pract. 2022;10:759–67.E1.

4. Arismendi E, Bantulà M, Perpiñá M, Picado C. Effects of obesity and asthma on lung function and airway dysanapsis in adults and children. J Clin Med. 2020;9:3762.

5. Forno E, Han YY, Mullen J, Celedón JC. Overweight, obesity, and lung function in children and adults—a meta-analysis. J Allergy Clin Immunol Pract. 2018;6:570–81.E10.