Gastrointestinal microbiome and coronavirus disease: evidence of a bidirectional association-Reference-Cited by-同舟云学术

Gastrointestinal microbiome and coronavirus disease: evidence of a bidirectional association

Published:2023-04-25 Issue: Volume: Page:157-165
ISSN:2692-3106
Container-title:Exploration of Medicine
language:
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Author:

Houston Kevin V.¹^ORCID,Patel Ankit²^ORCID,Saadeh Michael³^ORCID,Vargas Alejandra³^ORCID,Vilela Sangay Ana Rosa³^ORCID,D’Souza Steve M.³^ORCID,Yoo Byung Soo⁴^ORCID,Johnson David A.⁵^ORCID

Affiliation:

1. Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA

2. Department of Internal Medicine, George Washington University, Washington, D.C. 20052, USA

3. Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA

4. Department of Gastroenterology, Carolinas Medical Center, Charlotte, NC 28203, USA

5. Department of Gastroenterology, Eastern VA Medical School, Norfolk, VA 23507, USA

Abstract

The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the healthcare system with active disease, lasting effects, and complications with the full impact yet to be determined. The most current evidence of the interaction between COVID-19 and the GI microbiome is reviewed, with a focus on key mediators and the microbiome changes associated with acute disease and post-acute COVID-19 syndrome (PACS).

Publisher

Open Exploration Publishing

Subject

General Medicine

Reference40 articles.

1. Margolis KG, Cryan JF, Mayer EA. The microbiota-gut-brain axis: from motility to mood. Gastroenterology. 2021;160:1486–1501.

2. Marasco G, Lenti MV, Cremon C, Barbaro MR, Stanghellini V, Sabatino AD, et al. Implications of SARS-CoV-2 infection for neurogastroenterology. Neurogastroenterol Motil. 2021;33:e14104.

3. Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 2012;487:477–81.

4. Settanni CR, Ianiro G, Ponziani FR, Bibbò S, Segal JP, Cammarota G, et al. COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms. World J Gastroenterol. 2021;27:7433–45.

5. Zhang H, Li HB, Lyu JR, Lei XM, Li W, Wu G, et al. Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. Int J Infect Dis. 2020;96:19–24.