The differential effect of the immune system in breast cancer

Author:

Bondhopadhyay Banashree1ORCID,Hussain Showket2ORCID,Kasherwal Vishakha2

Affiliation:

1. Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida 201303, Uttar Pradesh, India

2. Molecular Diagnostics & Molecular Oncology, Molecular Biology Group, Division of Molecular Biology, ICMR-National Institute of Cancer Prevention and Research (NICPR), Noida 201301, Uttar Pradesh, India

Abstract

Cancer cure with immunotherapy is an innovative step towards cancer treatment with better survivability, but it is mostly dependent on the response of the patient’s immune system to the immunotherapeutic approach. This descriptive review article emphasizes the conventional and advanced treatment modalities currently available for breast cancer management. This review also highlights the clinical management of breast cancer concerning immune response especially to unravel the prospects for manipulation of immune cells: such as lymphocytes, including T-cells, T-regulatory cells and natural killer cells, and others like macrophages, dendritic cells, and the panel of interleukins or interferons released by them which has made a significant impact on breast cancer research. In addition, an effort was made to emphasize the different clinical trials and their future implication for the reduction of breast cancer cases. Overall, an attempt has been made to shed light on the possibilities of immunotherapeutics in breast cancer care, as well as the role of immune response in the incidence, aggressiveness, and survival of breast cancer.

Publisher

Open Exploration Publishing

Subject

Molecular Medicine

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