Group A streptococcal infection in the United Kingdom: an emerging threat

Author:

Zaman Kamran1ORCID,Siddiq Abdelmonem2ORCID,Mohanty Aroop3ORCID,León-Figueroa Darwin A.4ORCID,Barboza Joshuan J.5ORCID,AL-Ahdal Tareq6ORCID,Sah Ranjit7ORCID

Affiliation:

1. Department of Microbiology and Molecular Biology, ICMR-National Institute of Traditional Medicine, Belagavi 590010, Karnataka, India

2. Department of Pharmacy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

3. Department of Microbiology, All India Institute of Medical Sciences, Gorakhpur 273008, India

4. Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo 15011, Peru

5. Vicerrectorado de Investigación, Universidad Norbert Wiener, Lima 13001, Peru

6. Department of Medicine, Institute of Global Health, Heidelberg University, 69115 Heidelberg, Germany

7. Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu 44600, Nepal;Department of Microbiology, Dr. D.Y. Patil Medical College, Dr. D.Y. Patil Vidyapeeth, Pune 411018, Maharashtra, India;Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune 411018, Maharashtra, India

Abstract

Within group A Streptococcus (GAS), only Streptococcus pyogenes exhibits clinical significance. GAS is typed serologically based on unique surface proteins and critical virulence factors, such as a hyaluronic acid capsule that shields GAS from phagocytosis. The burden of GAS was estimated in the last five years as 14,000 to 25,000 cases of the invasive group A streptococcal disease in the USA with an estimated death from 1,500 to 2,300 cases per year. Early in the summer of 2022 in England, there was more scarlet fever than was anticipated. Early in the current season, the number of notifications rose to unusual heights. The analysis of invasive GAS (iGAS) isolate typing data shows that this season has seen a wide variety of encoding mature M protein (emm) gene sequence types found. Therefore, public health authorities should think about initiatives to increase clinicians’ and the general public’s awareness of GAS infections and to promote their quick diagnosis, molecular testing and antibiotic susceptibility testing, and standard treatment.

Publisher

Open Exploration Publishing

Subject

Molecular Medicine

Reference23 articles.

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2. Long SS, Prober CG, Fischer M. Streptococcus pyogenes (Group A Streptococcus). In: Principles and practice of pediatric infectious diseases. 5th ed. Philadelphia: Elsevier; 2017. pp. 3596–637.

3. Group A Streptococcus: information for clinicians [Internet]. Centers for Disease Control and Prevention; [cited 2022 Dec 22]. Available from: https://www.cdc.gov/groupastrep/diseases-hcp/index.html

4. Şahin A, Yüksel NC, Karadağ Öncel E, Kara Aksay A, Yılmaz N, Yılmaz Çiftdoğan D. Clinical and laboratory features of invasive Group A streptococcal infections: 8 years experience. Turk Arch Pediatr. 2022;57:75–80.

5. Horstmann RD, Sievertsen HJ, Leippe M, Fischetti VA. Role of fibrinogen in complement inhibition by streptococcal M protein. Infect Immun. 1992;60:5036–41.

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